Aafreen Ansari

Fate of human mesenchymal stromal/stem cells on patterned and dynamic hydrogels

Co-supervisors: Alex Combes, John Forsythe and Vinh Truong

Aafreen completed her M.Tech in Biotechnology from National Institute of Technology, Rourkela in 2020, where she explored the toxicological potential of multi-walled carbon nanotubes (MWCNT) on hepatocytes, under the supervision of Dr. Mukesh Kumar Gupta and Dr. Indranil Banerjee. Her study dealt with the controversy surrounding the cytotoxicity of carbon nanotubes which was analyzed by detailed evaluation of the dose-dependent response of hepatocytes against MWCNT, primarily focusing on the changes in hepatocellular functionalities. Post-graduation, she was part of a project entitled “A Novel Nanotechnology-based Approach of Glioma Therapy by Targeting HAUSP-MDM2 axis in combination with Temozolomide” at CSIR-Indian Institute of Chemical Biology, Kolkata as a Junior Research Fellow (JRF) under Dr. Mrinal Kanti Ghosh.  

In 2022, she joined the Frith lab at Monash University as a PhD student working on dynamic hydrogels for investigating the differential effect on MSCs fate. Her project hypotheses development of a patterned, photodynamic and reversible hydrogel system which could be used to study various cellular fates to find optimum elasticity of scaffold for future translation.